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The patients had been injected intramuscularly with 250 micrograms of carboprost at two hour intervals. In some patients, carboprost tromethamine may cause transient bronchoconstriction.ĭrug plasma concentrations were determined by radioimmunoassay in peripheral blood samples collected by different investigators from 10 patients undergoing abortion. With the clinical doses of carboprost tromethamine used for the termination of pregnancy, some patients do experience temperature increases.

In laboratory animals and also in humans carboprost tromethamine can elevate body temperature. With the doses of carboprost tromethamine used for terminating pregnancy, this effect has not been clinically significant. In laboratory animals and in humans large doses of carboprost tromethamine can raise blood pressure, probably by contracting the vascular smooth muscle. With the clinical doses of carboprost tromethamine used for the termination of pregnancy, and for use postpartum, some patients do experience transient temperature increases. This activity may produce the vomiting or diarrhea or both that is common when carboprost tromethamine is used to terminate pregnancy and for use postpartum. Postpartum, the resultant myometrial contractions provide hemostasis at the site of placentation.Ĭarboprost tromethamine also stimulates the smooth muscle of the human gastrointestinal tract. Nonetheless, they evacuate the products of conception from the uterus in most cases. Whether or not these contractions result from a direct effect of carboprost on the myometrium has not been determined.

Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy.

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